Spit changes after tooth removal

About this research

This study looks at how bone heals following tooth extraction, and whether saliva can be used to monitor the healing process.

Suitable participants would need to have a tooth that requires extraction and replacement with a dental implant.

You're eligible to participate in this study if you:

are aged between 18 and 75 years
need to have one tooth in the front of your mouth removed (with a single root, not a molar tooth) and replaced with a dental implant
have generally healthy gums
are able to attend multiple Brisbane-based appointments over the next 18 months
are generally healthy, with no major uncontrolled medical conditions that affect bone and gum healing
do not smoke or vape.

You may be ineligible to participate if you:

Participants will be asked to:

attend an initial appointment at the UQ School of Dentistry
have one tooth removed as part of your planned treatment
receive either standard natural healing or Assisted Ridge Preservation (a method used to support bone healing after tooth removal)
provide small saliva samples at a few time points (quick and non-invasive)
attend follow-up visits so we can monitor your healing
receive a dental implant as part of your treatment plan
attend follow-up appointments for up to 12 months after your dental implant placement.

Extra care: more frequent check-ups, imaging and follow-up than usual care
Reduced treatment costs: Graft materials (valued at around $500) are provided at no cost, and the dental implant is offered at a discounted rate (approximately $500 off).

If you meet the eligibility criteria and you're interested in participating, register your interest.

This study has been approved by The University of Queensland Human Research Ethics Committee [Approval No.2025/HE001107].

For any questions, please contact Lauren Williams: